Cyclophilin D inhibitors
Small drug molecule targeting Cyclophilin D for multiple sclerosis
Although multiple sclerosis (MS) is largely an autoimmune disorder in which the immune system erroneously attacks the sheaths surrounding neuronal axons, it is the death of these cells (neurodegeneration) itself that causes the long-term motor and cognitive deficits that are so devastating in this widespread disease. An optimised therapeutic approach should therefore target both immunomodulation and neurodegeneration in order to prevent chronic disability. This PoC project is aiming to complete lead optimisation from a series of novel small-molecule inhibitors of Cyclophilin D and to initiate pre-clinical evaluation.