Prof Stephen Neidle of the UCL School of Pharmacy and his team have developed a series of small-molecule compounds which bind to novel genetic targets associated with genomic dysfunctions which underlie cancer. This has the potential to open a new area of cancer therapeutics against well-established, but previously undruggable cancer targets. The UCL Technology Fund is directly supporting Prof Neidle’s lab with funding of up to £1m to deliver to a pre-clinical stage a first-in-class, optimised drug that will have superior efficacy against human pancreatic cancer, one of the most significant areas of unmet need in medicine. Standard current drug treatment (chemotherapy) has limited effects at best on improving patient survival in this devastating disease; the overall goal of this commercialisation program is to make a significant difference to survival for pancreatic cancer patients. The drug under investigation also has applicability to many other cancer types.
The team is developing a series of small-molecule compounds which bind to novel genetic targets associated with genomic dysfunctions which underlie cancer