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MSCTRAIL for mesothelioma

MSCTRAIL for mesothelioma

Clinical stage stem cell therapy for mesothelioma
Prof Sam Janes and his collaborators at UCL are currently investigating the use of MSCTRAIL cell therapy for non-small cell lung cancer (NSCLC) in human clinical trials. This innovative allogeneic therapy consists of mesenchymal stem cells (MSCs) that have been engineered to produce tumour necrosis factor-related apoptosis-inducing ligand (TRAIL); a molecule shown to preferentially induce cell death in cancer cells without affecting healthy cells. A UCLTF Licensing Project is now funding the use of MSCTRAIL in an additional biomarker-driven human clinical trial for malignant pleural mesothelioma (MPM). MPM is mainly caused by exposure to asbestos and affects the pleura; a membrane that forms the outer lining of the lungs and the inner lining of the chest cavity. It is currently incurable and causes more than 2,300 deaths a year in the UK alone.